Registration Dossier
Registration Dossier
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EC number: 242-354-0 | CAS number: 18472-51-0
Endpoint summary
Administrative data
Description of key information
Additional information
Studies on the acute toxicity of Chlorhexidine digluconate towards terrestrial organisms demonstrated that Chlorhexidine digluconate induced toxic effects at higher concentrations in plants, but not in earthworms or on microbial activity in soil.
Acute toxicity towards plants was tested on Avena sativa (oat), Glycine max (soy bean) and Brassica napus (rape) according to OECD guideline 208. No effects on seedling emergence were observed at the highest concentrations tested (NOECs were always ≥ 1000 mg a.i./kg dry soil). Seedling growth, as determined by shoot fresh-weight and -height, was a more sensitive endpoint display-ing EC50s between 526 and > 1000 mg a.i. /kg dry soil.
In a study according to the OECD guideline 207 on the acute toxicity of Chlorhexidine digluconate towards Eisenia fetida earthworms, the LC50 was determined to be > 1000 mg a.i./kg dry soil (limit test, 1000 mg/kg dry soil of Chlorhexidine digluconate 20%). No effects occurred at this concentration.
There is a study available on the inhibition of microbial activity in soils (nitrogen transformation study) with Chlorhexidine digluconate as test substance. In this study Chlorhexidine digluconate shows no effects after 28 days up to the highest concentration tested (1000 mg test item/kg dry weight corresponding to 193.4 mg a.i/kg dry weight). In addition the tests on the aquatic toxicity tests indicate that microorganisms are less sensitive to Chlorhexidine digluconate than the trophic levels algae, invertebrates and fish.
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