Registration Dossier
Registration Dossier
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EC number: 701-479-5 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980-07-31 to 1980-08-14
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study result presented as summary but includes all relevant information. Study was performed prior to implementation of GLP but carried out according to the principles of GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- Study was performed prior to implementation of GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- C18 (branched) fatty acids, esters with mono-, di-, and tri-glycerol
- EC Number:
- 701-479-5
- Molecular formula:
- C42H82O7
- IUPAC Name:
- C18 (branched) fatty acids, esters with mono-, di-, and tri-glycerol
- Test material form:
- other: clear light yellow liquid
- Details on test material:
- - Name of test material (as cited in study report): Hoe S 2721 = Fettsaeurepolyglycerinester
- Physical state: clear light yellow liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 5000 mg/kg body weight
- No. of animals per sex per dose:
- 10 females
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortallity occurred during the subsequent observation of 14 days.
- Clinical signs:
- other: Minor clinical symptoms, i.e. squatting posture, hair-raising, have been observed, but were reversible within 24 hours post application of test item.
- Gross pathology:
- The animals killed at the end of the observation period showed no macroscopcally visible changes.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the study results, the acute oral toxicity (LD50) of the test substance registered is greater than 5000 mg/kg body weight.
- Executive summary:
Based on the study results, the acute oral toxicity (LD50) of Hoe S 2721 in the rat is greater than 5000 mg/kg body weight. Accordingly Hoe S 2721 is not subject for labelling requirements with regard to acute oral toxicity.
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