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EC number: 219-440-1 | CAS number: 2437-25-4
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from computational model developed by USEPA.
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- ECOSAR estimates log Kow values using the US EPA's KOWWIN Program for aquatic toxicity.Toxicity of a chemical was measured on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program based upon the octanol /water partition coefficient (Kow). Data from ECOSAR class,neutral organics was used.
The estimation methods in EPI Suite™ have been developed by government, academic, and private sector researchers over many years and represent some of the best techniques currently available. The intended application domain of EPI Suite is organic chemicals, and inorganic as well as organometallic chemicals generally can be considered outside the domain. - GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test material: Dodecanenitrile
- Molecular formula: C12H23N
- Molecular weight: 181.321 g/mole
- Smiles notation: C(CCCCCC)CCCCC#N
- InChl: 1S/C12H23N/c1-2-3-4-5-6-7-8-9-10-11-12-13/h2-11H2,1H3
- Substance type: organic
- Physical state: colourless liquid - Analytical monitoring:
- not specified
- Details on sampling:
- No data available
- Vehicle:
- not specified
- Details on test solutions:
- No data available
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Common name: Water flea
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 21 d
- Post exposure observation period:
- No data available
- Hardness:
- No data available
- Test temperature:
- No data available
- pH:
- No data available
- Dissolved oxygen:
- No data available
- Salinity:
- No data available
- Conductivity:
- No data available
- Nominal and measured concentrations:
- No data available
- Details on test conditions:
- No data available
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.071 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- not specified
- Remarks on result:
- other: Neutral organics
- Details on results:
- No data available
- Results with reference substance (positive control):
- No data available
- Reported statistics and error estimates:
- No data available
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of EPI suite, ECOSAR version 1.1, the NOEC value for long term toxicity to aquatic invertebrates was predicted to be 0.071 mg/l for Dodecanenitrile in 21 days. Based on this value it can be concluded that the substance Dodecanenitrile is considered to be toxic to aquatic environment and can be consider to be classified in aquatic chronic 2 category as per the criteria mentioned in CLP regulation.
- Executive summary:
Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the NOEC value for long term toxicity to aquatic invertebrates was predicted.
On the basis of this program, the NOEC value for long term toxicity to aquatic invertebrates was predicted to be 0.071 mg/l for Dodecanenitrile in 21 days. Based on this value it can be concluded that the substance Dodecanenitrile is considered to be toxic to aquatic environment and can be consider to be classified in aquatic chronic 2 category as per the criteria mentioned in CLP regulation.
Reference
Description of key information
Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the NOEC value for long term toxicity to aquatic invertebrates was predicted. On the basis of this program, the NOEC value for long term toxicity to aquatic invertebrates was predicted to be 0.071 mg/l for Dodecanenitrile in 21 days. Based on this value it can be concluded that the substance Dodecanenitrile is considered to be toxic to aquatic environment and can be consider to be classified in aquatic acute 1/chronic 1 category as per the criteria mentioned in CLP regulation.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.071 mg/L
Additional information
Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the NOEC value for long term toxicity to aquatic invertebrates was predicted. On the basis of this program, the NOEC value for long term toxicity to aquatic invertebrates was predicted to be 0.071 mg/l for Dodecanenitrile in 21 days. Based on this value it can be concluded that the substance Dodecanenitrile is considered to be toxic to aquatic environment and can be consider to be classified in aquatic acute 1/chronic 1 category as per the criteria mentioned in CLP regulation.
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