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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from IUCLID Dataset

Data source

Reference
Reference Type:
secondary source
Title:
IUCLID Dataset of CAS 74-98-6
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCLID Dataset, EUROPEAN COMMISSION – European Chemicals Bureau

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute inhalation toxicity of Propane (CAS no: 74-98-6) in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
Propane
Cas Number:
74-98-6
Molecular formula:
C3H8
IUPAC Name:
Propane
Details on test material:
- Name of test material (as cited in study report): Propane
- Molecular formula (if other than submission substance): C3H8
- Molecular weight (if other than submission substance): 44.0962 g/mole
- Substance type: Organic
- Physical state: Gas
Specific details on test material used for the study:
- Name of test material (as cited in study report): Propane
- Molecular formula (if other than submission substance): C3H8
- Molecular weight (if other than submission substance): 44.0962 g/mole
- Substance type: Organic
- Physical state: Gas

Test animals

Strain:
other: Alderley Park
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
air
Remark on MMAD/GSD:
not specified
Details on inhalation exposure:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
15 min
Concentrations:
800000 ppm
No. of animals per sex per dose:
Groups of 6 male or 6 female
Control animals:
not specified
Details on study design:
- Other examinations performed: clinical signs, neuropathological examination was observed.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 800 000 mg/L air
Based on:
test mat.
Exp. duration:
15 min
Remarks on result:
other: No mortality was observed
Mortality:
Deaths occurred during the exposure and were associated with depressant effects on the central nervous system (CNS).
Clinical signs:
other: Lethal signs were observed in animals.The animals showed depressant effects on the central nervous system (CNS).
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The acute inhalation toxicity study in rat by using Propane for exposure of 15 min was considered to be > 800000 mg/L of air.
Executive summary:

In a acute inhalation toxicity study, Groups of 6 male or 6 female specific pathogen-free (SPS) Alderley Park rats were exposed to various concentrations of propane in air for 15 minutes.Deaths occurred during the exposure and were associated with depressant effects on the central nervous system (CNS). Also, lethal signs were observed in animals which are recovered within 10 minutes. Therefore, the acute inhalation toxicity study in rat by using Propane for exposure of 15 min was considered to be > 800000 mg/L of air.