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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Authorized database

Data source

Referenceopen allclose all

Reference Type:
other: Authorized database
Title:
Screening-Level Hazard Characterization Chemical Category Name Fatty Nitrogen Derived Nitriles
Author:
U.S. Environmental Protection Agency
Year:
2012
Bibliographic source:
HSDB (Hazardous Substances Data Bank), U.S. Environmental Protection Agency Hazard Characterization Document, March 2012
Reference Type:
secondary source
Title:
Fatty Nitrogen Derived Nitriles Category High Production Volume (HPV) Chemicals Challenge Program
Author:
Toxicology/Regulatory Services, Inc.
Year:
2003
Bibliographic source:
FND HPV Nitriles Robust Summaries, Page 1-239, 201-14980, December 29, 2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
To determine acute oral toxicity in rat using Dodecanenitrile by OECD Guideline 401 Acute Oral Toxicity.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dodecanenitrile
EC Number:
219-440-1
EC Name:
Dodecanenitrile
Cas Number:
2437-25-4
Molecular formula:
C12H23N
IUPAC Name:
dodecanenitrile
Details on test material:
SMILES:CCCCCCCCCCCC#N
Specific details on test material used for the study:
- Name of test material (as cited in study report): Dodecanenitrile
- Molecular formula (if other than submission substance): C12H23N
- Molecular weight (if other than submission substance): 181.321 g/mol
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
3400 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 400 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality was observed
Mortality:
50 % mortality was observed at 3400 mg/kg bw in treated rats
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not toxic
Conclusions:
LD50 was considered to be 3400 mg/kg bw when rats were treated with Dodecanenitrile orally.
Executive summary:

In a acute oral toxicity study, rat were treated with Dodecanenitrile in the concentration of 3400 mg/kg bw orally. 50% mortality was observed at 3400 mg/kg bw in treated rats. Therefore, LD50 was considered to be 3400 mg/kg bw when rats were treated with Dodecanenitrile orally. Based on this value and comparing it with CLP classification criteria it can be concluded that the substance Dodecanenitrile is not toxic via oral route of administration and considered as Not classified.