Dodecanenitrile

Endpoint summary

Description of key information

Skin irritation:

The dermal irritation potential of Dodecanenitrile (CAS No: 2437-25-4) was estimated using OECD QSAR toolbox version 3.4 with logPow as the primary descriptor. The substance Dodecanenitrile (CAS No: 2437-25-4) was estimated to be irritating to the skin of New Zealand White rabbits. Based on the estimated result Dodecanenitrile (CAS No: 2437-25-4) can be considered to be irritating to skin and can be classified under the category ˋ Category 2 (irritant)’ as per CLP regulation.

Eye irritation:

The ocular irritation potential of Dodecanenitrile (CAS No: 2437-25-4) was estimated using OECD QSAR toolbox version 3.4 with logPow as the primary descriptor. The substance Dodecanenitrile (CAS No: 2437-25-4) was estimated to be not irritating into the eyes of rabbits. Based on the estimated result Dodecanenitrile (CAS No: 2437-25-4) can be considered to be not irritating to eye and can be classified under the category ˋ Not Classified’ as per CLP regulation.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Reference

Endpoint:

skin irritation: in vivo

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

Data is from OECD QSAR toolbox version 3.4 and QMRF report has been attached

Qualifier:

according to guideline

Guideline:

other: Estimated data

Principles of method if other than guideline:

Prediction is done using QSAR Toolbox version 3.4

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material (IUPAC name): Dodecanenitrile
- Molecular formula: C12H23N
- Molecular weight: 181.321 g/mole
- Smiles notation: C(CCCCCC)CCCCC#N
- InChl: 1S/C12H23N/c1-2-3-4-5-6-7-8-9-10-11-12-13/h2-11H2,1H3
- Substance type: Organic
- Physical state: colourless liquid

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

No data available

Type of coverage:

semiocclusive

Preparation of test site:

shaved

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

No data available

Duration of treatment / exposure:

4 hours

Observation period:

72 hours

Number of animals:

3

Details on study design:

No data available

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

72 h

Reversibility:

not specified

Remarks on result:

positive indication of irritation

Irritant / corrosive response data:

Skin irritation was observed in treated rabbits.

Estimation method: Takes mode value from the 5 nearest neighbours
Domain  logical expression:Result: In Domain

((((((((((((((((("a" or "b" or "c" or "d" )  and ("e" and ( not "f") )  )  and ("g" and ( not "h") )  )  and ("i" and ( not "j") )  )  and ("k" and ( not "l") )  )  and ("m" and ( not "n") )  )  and ("o" and ( not "p") )  )  and ("q" and ( not "r") )  )  and ("s" and ( not "t") )  )  and ("u" and ( not "v") )  )  and ("w" and ( not "x") )  )  and ("y" and ( not "z") )  )  and ("aa" and ( not "ab") )  )  and "ac" )  and "ad" )  and "ae" )  and ("af" and "ag" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Nitrile by Organic Functional groups

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Nitrile by Organic Functional groups (nested)

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Acetylenic Carbon [#C] AND Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Cyano, aliphatic attach [-C#N] by Organic functional groups (US EPA)

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Nitrile by Organic functional groups, Norbert Haider (checkmol)

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as Inclusion rules not met by Skin irritation/corrosion Inclusion rules by BfR

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as Aromatic amines OR Ketones OR Phenols by Skin irritation/corrosion Inclusion rules by BfR

Domain logical expression index: "g"

Referential boundary: The target chemical should be classified as (!Undefined)Group All Lipid Solubility < 0.01 g/kg AND (!Undefined)Group CN Lipid Solubility < 0.4 g/kg AND Group CN Aqueous Solubility < 0.1 g/L AND Group CN log Kow > 4.5 by Skin irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "h"

Referential boundary: The target chemical should be classified as Group CN log Kow > 5.5 OR Group CN Melting Point > 180 C by Skin irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "i"

Referential boundary: The target chemical should be classified as (!Undefined)Group All Lipid Solubility < 0.01 g/kg AND (!Undefined)Group CN Lipid Solubility < 0.4 g/kg AND Group CN Aqueous Solubility < 0.1 g/L AND Group CN log Kow > 4.5 by Skin irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "j"

Referential boundary: The target chemical should be classified as Group CNHal Aqueous Solubility < 0.1 g/L by Skin irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "k"

Referential boundary: The target chemical should be classified as (!Undefined)Group All Lipid Solubility < 0.01 g/kg AND (!Undefined)Group CN Lipid Solubility < 0.4 g/kg AND Group CN Aqueous Solubility < 0.1 g/L AND Group CN log Kow > 4.5 by Skin irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "l"

Referential boundary: The target chemical should be classified as Group CNS Melting Point > 120 C by Skin irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "m"

Referential boundary: The target chemical should be classified as No alert found by Protein binding alerts for skin sensitization by OASIS v1.4

Domain logical expression index: "n"

Referential boundary: The target chemical should be classified as Michael Addition OR Michael Addition >> Michael addition on conjugated systems with electron withdrawing group OR Michael Addition >> Michael addition on conjugated systems with electron withdrawing group >> Cyanoalkenes OR SN2 OR SN2 >> Nucleophilic substitution on benzilyc carbon atom OR SN2 >> Nucleophilic substitution on benzilyc carbon atom >> alpha-Activated benzyls  OR SN2 >> SN2 Reaction at a sp3 carbon atom OR SN2 >> SN2 Reaction at a sp3 carbon atom >> Activated alkyl esters and thioesters  by Protein binding alerts for skin sensitization by OASIS v1.4

Domain logical expression index: "o"

Referential boundary: The target chemical should be classified as No alert found by Carcinogenicity (genotox and nongenotox) alerts by ISS

Domain logical expression index: "p"

Referential boundary: The target chemical should be classified as Aliphatic azo and azoxy (Genotox) OR Halogenated benzene (Nongenotox) OR Hydrazine (Genotox) OR Nitro-aromatic (Genotox) OR Primary aromatic amine,hydroxyl amine and its derived esters (Genotox) OR Structural alert for genotoxic carcinogenicity OR Structural alert for nongenotoxic carcinogenicity OR Substituted n-alkylcarboxylic acids (Nongenotox) by Carcinogenicity (genotox and nongenotox) alerts by ISS

Domain logical expression index: "q"

Referential boundary: The target chemical should be classified as Nitrile by Organic Functional groups

Domain logical expression index: "r"

Referential boundary: The target chemical should be classified as tert-Butyl by Organic Functional groups

Domain logical expression index: "s"

Referential boundary: The target chemical should be classified as Nitrile by Organic Functional groups

Domain logical expression index: "t"

Referential boundary: The target chemical should be classified as Terpenes by Organic Functional groups

Domain logical expression index: "u"

Referential boundary: The target chemical should be classified as Nitrile by Organic Functional groups

Domain logical expression index: "v"

Referential boundary: The target chemical should be classified as Organic amide and thioamide OR Phosphinate ester OR Silane OR Sulfide by Organic Functional groups

Domain logical expression index: "w"

Referential boundary: The target chemical should be classified as Nitrile by Organic Functional groups

Domain logical expression index: "x"

Referential boundary: The target chemical should be classified as Ether by Organic Functional groups

Domain logical expression index: "y"

Referential boundary: The target chemical should be classified as Nitrile by Organic Functional groups

Domain logical expression index: "z"

Referential boundary: The target chemical should be classified as Biphenyl by Organic Functional groups

Domain logical expression index: "aa"

Referential boundary: The target chemical should be classified as Nitrile by Organic Functional groups

Domain logical expression index: "ab"

Referential boundary: The target chemical should be classified as Aryl halide OR Carboxylic acid by Organic Functional groups

Domain logical expression index: "ac"

Similarity boundary:Target: CCCCCCCCCCCC#N
Threshold=20%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization

Domain logical expression index: "ad"

Similarity boundary:Target: CCCCCCCCCCCC#N
Threshold=30%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization

Domain logical expression index: "ae"

Similarity boundary:Target: CCCCCCCCCCCC#N
Threshold=80%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization

Domain logical expression index: "af"

Parametric boundary:The target chemical should have a value of log Kow which is >= 2.4

Domain logical expression index: "ag"

Parametric boundary:The target chemical should have a value of log Kow which is <= 4.96

Interpretation of results:

Category 2 (irritant) based on GHS criteria

Conclusions:

The substance Dodecanenitrile (CAS No: 2437-25-4) was estimated to be irritating to the skin of New Zealand White rabbits. Based on the estimated result Dodecanenitrile (CAS No: 2437-25-4) can be considered to be irritating to skin.

Executive summary:

The dermal irritation potential of Dodecanenitrile (CAS No: 2437-25-4) was estimated using OECD QSAR toolbox version 3.4 with logPow as the primary descriptor. The substance Dodecanenitrile (CAS No: 2437-25-4) was estimated to be irritating to the skin of New Zealand White rabbits. Based on the estimated result Dodecanenitrile (CAS No: 2437-25-4) can be considered to be irritating to skin and can be classified under the category ˋ Category 2 (irritant)’ as per CLP regulation.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Eye irritation

Link to relevant study records

Reference

Endpoint:

eye irritation: in vivo

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

Data is from OECD QSAR toolbox version 3.4 and QMRF report has been attached

Qualifier:

according to guideline

Guideline:

other: estimated data

Principles of method if other than guideline:

Prediction is done using QSAR Toolbox version 3.4

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material (IUPAC name): Dodecanenitrile
- Molecular formula: C12H23N
- Molecular weight: 181.321 g/mole
- Smiles notation: C(CCCCCC)CCCCC#N
- InChl: 1S/C12H23N/c1-2-3-4-5-6-7-8-9-10-11-12-13/h2-11H2,1H3
- Substance type: Organic
- Physical state: colourless liquid

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

No data available

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

No data available

Duration of treatment / exposure:

72 hours

Observation period (in vivo):

24/48/72 hours

Duration of post- treatment incubation (in vitro):

No data available

Number of animals or in vitro replicates:

No data available

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

24/48/72 h

Reversibility:

not specified

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

No eye irritation was observed.

Estimation method: Takes mode value from the 7 nearest neighbours
Domain  logical expression:Result: In Domain

(((((((((("a" or "b" or "c" or "d" )  and ("e" and ( not "f") )  )  and ("g" and ( not "h") )  )  and "i" )  and ("j" and ( not "k") )  )  and "l" )  and "m" )  and "n" )  and "o" )  and ("p" and "q" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Nitrile by Organic Functional groups

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Nitrile by Organic Functional groups (nested)

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Acetylenic Carbon [#C] AND Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Cyano, aliphatic attach [-C#N] by Organic functional groups (US EPA)

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Nitrile by Organic functional groups, Norbert Haider (checkmol)

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as No alert found by Protein binding by OASIS v1.4

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as Acylation OR Acylation >> Acylation involving an activated (glucuronidated) ester group OR Acylation >> Acylation involving an activated (glucuronidated) ester group >> Arenecarboxylic Acid Esters OR Acylation >> Ester aminolysis OR Acylation >> Ester aminolysis >> Amides OR AN2 OR AN2 >> Michael addition to activated double bonds OR AN2 >> Michael addition to activated double bonds >> alpha,beta-Unsaturated Carbonyls and Related Compounds OR AN2 >> Michael addition to alpha, beta-unsaturated acids and esters OR AN2 >> Michael addition to alpha, beta-unsaturated acids and esters >> alpha,beta-Unsaturated Carboxylic Acids and Esters OR AN2 >> Michael type addition to activated double bond of pyrimidine bases OR AN2 >> Michael type addition to activated double bond of pyrimidine bases >> Pyrimidines and Purines OR AN2 >> Michael-type addition to quinoid structures  OR AN2 >> Michael-type addition to quinoid structures  >> N-Substituted Aromatic Amines OR AN2 >> Michael-type addition to quinoid structures  >> Substituted Anilines OR AN2 >> Michael-type addition to quinoid structures  >> Substituted Phenols OR AN2 >> Schiff base formation with carbonyl group of pyrimidine and purine bases OR AN2 >> Schiff base formation with carbonyl group of pyrimidine and purine bases >> Pyrimidines and Purines OR Michael addition OR Michael addition >> Michael addition on conjugated systems with electron withdrawing group OR Michael addition >> Michael addition on conjugated systems with electron withdrawing group >> Cyanoalkenes OR Nucleophilic addition OR Nucleophilic addition >> Addition to carbon-hetero double bonds OR Nucleophilic addition >> Addition to carbon-hetero double bonds >> Ketones OR SN2 OR SN2 >> Cyanoalkylation of proteins via the nucleophilic substitution at sp3-carbon atom of cyanohydrins OR SN2 >> Cyanoalkylation of proteins via the nucleophilic substitution at sp3-carbon atom of cyanohydrins >> Cyanohydrins OR SN2 >> Nucleophilic substitution on benzilyc carbon atom OR SN2 >> Nucleophilic substitution on benzilyc carbon atom >> alpha-Activated benzyls  OR SN2 >> SN2 Reaction at a sp3 carbon atom OR SN2 >> SN2 Reaction at a sp3 carbon atom >> Activated alkyl esters and thioesters  OR SN2 >> Thiocyanate formation via the nucleophilic-type substitution at the disulfide bond of proteins and enzymes OR SN2 >> Thiocyanate formation via the nucleophilic-type substitution at the disulfide bond of proteins and enzymes >> Cyanohydrins by Protein binding by OASIS v1.4

Domain logical expression index: "g"

Referential boundary: The target chemical should be classified as No alert found by Protein binding by OECD

Domain logical expression index: "h"

Referential boundary: The target chemical should be classified as Acylation OR Acylation >> Direct Acylation Involving a Leaving group OR Acylation >> Direct Acylation Involving a Leaving group >> Acetates OR Acylation >> Direct Acylation Involving a Leaving group >> Azlactone OR SN2 OR SN2 >> SN2 reaction at sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon atom >> Allyl acetates and related chemicals OR SN2 >> SN2 reaction at sp3 carbon atom >> alpha-Haloalkenes (and related cyano, sulfate and sulfonate subs. chem.) by Protein binding by OECD

Domain logical expression index: "i"

Referential boundary: The target chemical should be classified as No superfragment by Superfragments ONLY

Domain logical expression index: "j"

Referential boundary: The target chemical should be classified as Inclusion rules not met by Skin irritation/corrosion Inclusion rules by BfR

Domain logical expression index: "k"

Referential boundary: The target chemical should be classified as Ketones by Skin irritation/corrosion Inclusion rules by BfR

Domain logical expression index: "l"

Similarity boundary:Target: CCCCCCCCCCCC#N
Threshold=10%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization

Domain logical expression index: "m"

Similarity boundary:Target: CCCCCCCCCCCC#N
Threshold=30%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization

Domain logical expression index: "n"

Similarity boundary:Target: CCCCCCCCCCCC#N
Threshold=40%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization

Domain logical expression index: "o"

Similarity boundary:Target: CCCCCCCCCCCC#N
Threshold=50%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization

Domain logical expression index: "p"

Parametric boundary:The target chemical should have a value of log Kow which is >= 2.8

Domain logical expression index: "q"

Parametric boundary:The target chemical should have a value of log Kow which is <= 5.61

Interpretation of results:

other: not irritating

Conclusions:

The substance Dodecanenitrile (CAS No: 2437-25-4) was estimated to be not irritating into the eyes of rabbits. Based on the estimated result Dodecanenitrile (CAS No: 2437-25-4) can be considered to be not irritating to eye.

Executive summary:

The ocular irritation potential of Dodecanenitrile (CAS No: 2437-25-4) was estimated using OECD QSAR toolbox version 3.4 with logPow as the primary descriptor. The substance Dodecanenitrile (CAS No: 2437-25-4) was estimated to be not irritating into the eyes of rabbits. Based on the estimated result Dodecanenitrile (CAS No: 2437-25-4) can be considered to be not irritating to eye and can be classified under the category ˋ Not Classified’ as per CLP regulation.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Skin irritation:

Various studieshas been investigated for the test chemical Dodecanenitrile (CAS No: 2437-25-4) to observe the potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits and guinea pigs for target chemical Dodecanenitrile (CAS No: 2437-25-4) and its structurally similar read across substances Myristonitrile (CAS No: 629-63-0) and Butanenitrile (CAS No: 109-74-0). The predicted data using the OECD QSAR toolbox has also been compared with the experimental data and summarized as below;

 

In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the skin irritation potential was estimated for test chemicalDodecanenitrile (CAS No: 2437-25-4) .The chemical Dodecanenitrile (CAS No: 2437-25-4) is estimated to be irritating to skin of New Zealand White rabbits.

 

The D. L. J. Opdyke (2000) conducted skin irritation study ofstructurally similar read across substanceMyristonitrile (CAS No: 629-63-0) on six guinea pigs as part of an open epicutaneous test during the 21-day induction period which supports the above mentioned result. In this test, a 0.1 ml aliquot of the test material was applied to an 8cm²area on the clipped flanks of six guinea pigs once daily for 21 consecutive days. Reactions were read 24 hr after application.The treated guinea pigs produced moderate to strong skin irritation reactions. Hence under this experimental condition, the chemicalMyristonitrile (CAS No: 629-63-0) was considered to be irritating to the guinea pigs’ skin.

 

The above results were further supported by experimental study reported by RTECS ® (2017) forstructurally similar read across substanceButanenitrile (CAS No: 109-74-0) on rabbits under non-occlusive condition. About 395 mg of Butanenitrile was applied onto the skin of each rabbit and later examined for skin reaction. The rabbits showed mild skin irritating effects. Hence the chemical, Butanenitrile (CAS No: 109-74-0) wasconsidered to beirritatingto therabbits’ skin.

 

Thus on the basis of available data for the target chemical Dodecanenitrile (CAS No: 2437-25-4) and its structurally similar read across substances Myristonitrile (CAS No: 629 -63 -0) and Butanenitrile (CAS No: 109-74-0),it can be concluded that chemical Dodecanenitrile (CAS No: 2437-25-4) is able to cause skin irritation and considered as irritating.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Category 2(irritant)”.

 

 

Eye irritation:

In different studies,the test chemicalDodecanenitrile (CAS No: 2437-25-4) has been investigated for potential for ocular irritationto a greater or lesser extent. The studies are based on in vivo experiments in rabbits for target chemical Dodecanenitrile (CAS No: 2437 -25 -4) and its closest read across substance usinglog Pow as the primary descriptor 2,2'-Azobis(isobutyronitrile)(CAS No: 78-67-1) and 2,2'-Azobis(2-methylbutyronitrile) (CAS No: 13472-08-7).The predicted data using the OECD QSAR toolbox has also been compared with the experimental data and summarized as below;

 

In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the eye irritation potential was estimated for test chemicalDodecanenitrile (CAS No: 2437-25-4) .The chemical Dodecanenitrile (CAS No: 2437-25-4) is estimated to be not irritating to eye of rabbits.

 

The OECD SIDS -United Nations Environmental Programme (UNEP, 1999) reported an ocular irritation study for readacross substance 2,2'-Azobis(isobutyronitrile)(CAS No: 78-67-1) in New Zealand White rabbits in accordance with OECD TG 405 and EC TG 92/69/E.E.C., B5. A single dose of 100 mg of 2,2'-azobis(2-methylpropanitrile) in original form of was administered into the conjunctival sac of the left eye by gently pulling the lower lid away from the eyeball while the right eye, which remained untreated, served as a control. The eyes were not rinsed and examined approximately one hour, 24, 48 and 72 hours after administration. The treated rabbits did not produce any ocular lesions. Hence the chemical2,2'-Azobis(isobutyronitrile) (CAS No: 78 -67 -1) was considered to be not irritating to the New Zealand White rabbits’ eye.

 

The above results were further supported by the experimental study conducted on two male albino rabbits for the readacross substance2,2'-Azobis(2-methylbutyronitrile) (CAS No: 13472-08-7) by U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxics (OPPT) Risk Assessment Division (RAD, 2002) under occlusive condition. The solid test substance (28.4 mg) was placed into the right conjunctival sac of each of 2 male albino rabbits. After 20 seconds, 1 treated eye was washed with tap water for 1 minute. The treated eye of the other rabbit was not washed. Observations of the cornea, iris, and conjunctiva were made with a hand-slit lamp at 1 and 4 hours, and at 1, 2, and 3 days. Fluor-i-strip®stain and a biomicroscope wereused at examinations after the day of treatment. The test substance produced no corneal, iritic, or conjunctival effects at any time when tested in rabbit eyes. Hencethe chemical2,2'-Azobis(2-methylbutyronitrile) (CAS No: 13472-08-7)was considered to be not irritating to the rabbits’ eye.

 

Thus on the basis of available data for the target chemical Dodecanenitrile (CAS No: 2437-25-4) and its closet read across substance using log Pow as the primary descriptor 2,2'-Azobis(isobutyronitrile) (CAS No: 78 -67 -1) and 2,2'-Azobis(2 -methylbutyronitrile) (CAS No: 13472 -08 -7), it can be concluded that chemical Dodecanenitrile (CAS No: 2437 -25 -4) is unable to cause eye irritation and considered as not irritating. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.

Justification for classification or non-classification

The skin and eye irritation potential of test chemical Dodecanenitrile (CAS No: 2437-25-4) and its read across substances were observed in various studies. The results obtained from these studies indicate that the chemical Dodecanenitrile (CAS No: 2437-25-4) is able to cause skin irritation but unlikely to cause ocular lesions. Hence Dodecanenitrile (CAS No: 2437-25-4) can be classified under the category “Category 2 (irritant)” for skin and “Not Classified” for eye as per CLP classification criteria.